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Cmax of meprobamate was 2.5 ± 0.5 g / ml (mean ± SD) after administration of single doses of 350, carisoprodol, which is about 30% of the Cmax of meprobamate (buy soma 250mg Newport News approximately 8 g / ml) after administration of a single dose of 400 mg of meprobamate. Absorption The absolute bioavailability of carisoprodol has not been determined. The median time to maximum plasma concentration (buy soma 250mg Newport News Tmax) of carisoprodol was approximately 1.5 to 2 hours. Concomitant administration of a high-fat meal, and carisoprodol (350 mg) had no effect on the pharmacokinetics of carisoprodol. Therefore, carisoprodol can be taken with or without food. Metabolism: The major pathway of carisoprodol metabolism is the liver by CYP2C19 to form meprobamate. This enzyme exhibits genetic polymorphism (see Patients with Reduced CYP2C19 Activity below). Elimination: Carisoprodol is eliminated by two-way non-renal failure and with a terminal elimination half-life of about 2 hours. The half-life of meprobamate is approximately 10 hours. Gender: The exposure of carisoprodol is higherwomen than in men (about 3.050% on a weight-adjusted). The overall exposure of meprobamate is comparable between male and female subjects.

Patients with reduced CYP2C19 activity: Carisoprodol should be used with caution in patients with reduced CYP2C19 activity. Published studies indicate buy soma 250mg Newport News that patients who are CYP2C19 poor metabolizers have a 4 buy soma 250mg Newport News times increase in exposure to carisoprodol, and buy soma 250mg Newport News concomitant exposure to 50% decrease compared with normal CYP2C19 metabolizers meprobamate. The prevalence of poor metabolizers in Caucasians and African Americans is about 35% and in Asians is approximately 1.520%. The long-term studies in animals have not been buy soma 250mg Newport News conducted to evaluate the carcinogenic potential of carisoprodol. Carisoprodol is not formally evaluated for genotoxicity. In published studies, carisoprodol was mutagenic in the in vitro test of mouse lymphoma cells in the absence of metabolizing enzymes, but was not mutagenic in the presence of metabolizing enzymes.

Carisoprodol was clastogenic in the chromosomal aberration test in vitro with cells of Chinese hamster ovary, with or without the presence of metabolizing enzymes.